The Bracha Lab for Disordered Subcellular Systems
From molecular disorder to cellular function and dysfunction
Our lab develops bioengineered tools to investigate the self-organization and function of disordered protein assemblies, also known as biomolecular condensates. These subcellular structures play key roles in coordinating complex cellular processes, from gene regulation and genome organization to stress response, signaling, and disease-associated cellular reprogramming.
At the core of these structures are protein building blocks, most of which are largely unstructured, that can dynamically interact with multiple partners to undergo liquid-liquid phase separation - a physicochemical phase transition that has been refined by evolution into advantageous modes of action. While science is only beginning to uncover the full extent of condensate physiology, disruptions in their material state and collective interactions have already been linked to various neurodegenerative disorders and cancers - underscoring the need to uncover their underlying mechanisms.
Our lab employs a multidisciplinary approach that integrates quantitative cell biology, optogenetic designs, and advanced imaging to uncover the principles governing the biogenesis, responsive composition, function, and dysfunction of these dynamic systems in cellular health and disease. Ultimately, we aim to translate these fundamental insights and technologies into next-generation genomic and metabolic engineering tools and innovative therapeutic strategies.
At the core of these structures are protein building blocks, most of which are largely unstructured, that can dynamically interact with multiple partners to undergo liquid-liquid phase separation - a physicochemical phase transition that has been refined by evolution into advantageous modes of action. While science is only beginning to uncover the full extent of condensate physiology, disruptions in their material state and collective interactions have already been linked to various neurodegenerative disorders and cancers - underscoring the need to uncover their underlying mechanisms.
Our lab employs a multidisciplinary approach that integrates quantitative cell biology, optogenetic designs, and advanced imaging to uncover the principles governing the biogenesis, responsive composition, function, and dysfunction of these dynamic systems in cellular health and disease. Ultimately, we aim to translate these fundamental insights and technologies into next-generation genomic and metabolic engineering tools and innovative therapeutic strategies.
Funding Resources
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